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Fletta eftir efnisorði "Sickle cell disease"

Fletta eftir efnisorði "Sickle cell disease"

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    POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression 
    Gudmundsdottir, Bjorg; Gudmundsson, Kristbjorn Orri; Klarmann, Kimberly D.; Singh, Satyendra K.; Sun, Lei; Singh, Shweta; Du, Yang; Coppola, Vincenzo; Stockwin, Luke; Nguyen, Nhu; Tessarollo, Lino; Thorsteinsson, Leifur; Sigurjonsson, Olafur; Gudmundsson, Sveinn Vidar; Rafnar, Thorunn; Tisdale, John F.; Keller, Jonathan R. (Elsevier BV, 2018-06-12)
    Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identified a zinc-finger ...
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    Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy 
    Stukenborg, J -B; Alves-Lopes, J P; Kurek, M; Albalushi, H; Reda, A; Keros, V; Töhönen, V; Bjarnason, Ragnar Grímur; Romerius, P; Sundin, M; Norén Nyström, U; Langenskiöld, C; Vogt, H; Henningsohn, L; Mitchell, R T; Söder, O; Petersen, C; Jahnukainen, K (Oxford University Press (OUP), 2018-07-25)
    STUDY QUESTION: Does chemotherapy exposure (with or without alkylating agents) or primary diagnosis affect spermatogonial quantity in human prepubertal testicular tissue? SUMMARY ANSWER: Spermatogonial quantity is significantly reduced in testes of ...